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Search Results for " tyrosine kinase "

ターゲット

Tyrosine Kinases VEGFR FGFR FLT PDGFR

579

阻害剤

天然化合物

687

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T5466	Tyrosine kinase-IN-1		VEGFR , FGFR , FLT , PDGFR
	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）		VEGFR , FGFR , FLT , PDGFR
T60108	PDGFR Tyrosine Kinase Inhibitor III	PDGF Receptor Tyrosine Kinase Inhibitor III	PDGFR
	PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF...		PDGFR
T77746	Tyrosine kinase-IN-7		EGFR , Antiviral
	Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines. Tyrosine kinase-IN-7 has pote...		EGFR , Antiviral
T39178	Tyrosine Kinase Peptide 1
	Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay.
T17184	Tyrosine kinase inhibitor		c-Met/HGFR , Tyrosine Kinases
	Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.		c-Met/HGFR , Tyrosine Kinases
T41099	EGFR Protein Tyrosine Kinase Substrate
	EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate.
TP1269	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)	Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.
T4344	ALW-II-41-27	Eph receptor tyrosine kinase inhibitor	Ephrin Receptor
	ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor), an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy.		Ephrin Receptor
T21761	HNMPA		IGF-1R
	HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase. HNMPA inhibits tyrosine and serine autophosphorylation by the human insulin receptor. HNMPA exhibits no effect on cyclic AMP-dependent prote...		IGF-1R
TQ0111	LDN-192960		DYRK , Haspin Kinase
	LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).		DYRK , Haspin Kinase
T16730	Remibrutinib		BTK
	Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticar...		BTK
T2431	ID-8	ID8	DYRK
	ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.		DYRK
T11447	GNF4877		GSK-3 , DYRK
	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.		GSK-3 , DYRK
T2314	PF-431396		FAK , PYK2
	PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).		FAK , PYK2
T14692	BMX-IN-1	BMX kinase inhibitor	BTK
	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 ...		BTK
T6257	AZ191		DYRK
	AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.		DYRK
T15422	GSK-626616		DYRK
	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.		DYRK
T79612	Tyrosine kinase-IN-6		c-Met/HGFR
	Tyrosine kinase-IN-6 is a potent inhibitor of RON splice variants, demonstrating significant anticancer and antineoplastic effects [1].		c-Met/HGFR
T14980	CLK-IN-T3		DYRK , CDK
	CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.		DYRK , CDK
T61730	Tyrosine kinase-IN-4
	Tyrosine kinase-IN-4 (EXAMPLE 107) is a protein tyrosine kinase inhibitor [1].
T3041	ALK inhibitor 2		FAK , ALK
	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.		FAK , ALK
T2655	CEP-37440	CEP37440	FAK , ALK
	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).		FAK , ALK
T4209	TAK-659 hydrochloride	TAK-659	VEGFR , FLT , Tyrosine Kinases , JAK , Syk
	TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.		VEGFR , FLT , Tyrosine Kinases , JAK , Syk
T6217	LFM-A13		PLK , JAK , BTK
	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.		PLK , JAK , BTK
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T2465	PF-562271	PF562271,PF 562271	FAK , PYK2 , CDK
	PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).		FAK , PYK2 , CDK
T11254	F-1		ROS , ALK , ROS Kinase
	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa...		ROS , ALK , ROS Kinase
T3079	GSK1838705A		IGF-1R , JNK , S6 Kinase , ALK
	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.		IGF-1R , JNK , S6 Kinase , ALK
T6177	PF-562271 besylate	PF-00562271 Besylate	FAK , PYK2 , CDK
	PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc...		FAK , PYK2 , CDK
T6115	Fostamatinib	R788	FLT , Syk , Monoamine Transporter , Adenosine Receptor
	Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.		FLT , Syk , Monoamine Transporter , Adenosine Receptor
T6409	ALK kinase inhibitor-1	SAR348830	Others
	SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.		Others
T9576	AMP-945		FAK
	AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.		FAK
T9125	Tolebrutinib	PRN2246,SAR442168	BTK
	Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits effi...		BTK
T6997	SU6656		FAK , Akt , Src
	SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.		FAK , Akt , Src
T1967	AZD-3463	ALK/IGF1R inhibitor	Apoptosis , IGF-1R , ALK , Autophagy
	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.		Apoptosis , IGF-1R , ALK , Autophagy
T15612	JH-VIII-157-02		Microtubule Associated , ALK
	JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L...		Microtubule Associated , ALK
T16153	MS4078		ALK , Ligand for E3 Ligase
	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.		ALK , Ligand for E3 Ligase
T10626	(Rac)-IBT6A		Others , BTK
	(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.		Others , BTK
T3061	Lorlatinib	PF-6463922,PF-06463922,Loratinib	Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
	Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.		Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T16776	RO9021		Syk
			Syk
T1976	RN486		BTK
	RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).		BTK
T14331	Gusacitinib	ASN-002	JAK , Syk
	Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).		JAK , Syk
T2612	CEP-28122		ALK
	CEP-28122 is a highly potent and selective orally active ALK inhibitor.		ALK
T2620	G-749	G749	Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
	G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.		Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
T9973	FAK-IN-7		FAK
	FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.		FAK
T1962	ASP3026	ASP 3026	Apoptosis , ALK
	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.		Apoptosis , ALK
T2001	PF-573228	PF 573228	Apoptosis , FAK
	PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.		Apoptosis , FAK
T6174	R406	R-406 besylate	Apoptosis , FLT , Syk
	R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.		Apoptosis , FLT , Syk
T5138	BMS-986142		BTK
	BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).		BTK

Compounds

Tyrosine kinase-IN-1

T5466

Synonym:

Target: VEGFR, FGFR, FLT, PDGFR

PDGFR Tyrosine Kinase Inhibitor III

T60108

Synonym: PDGF Receptor Tyrosine Kinase Inhibitor III

Target: PDGFR

Tyrosine kinase-IN-7

T77746

Synonym:

Target: EGFR, Antiviral

Tyrosine Kinase Peptide 1

T39178

Synonym:

Target:

Tyrosine kinase inhibitor

T17184

Synonym:

Target: c-Met/HGFR, Tyrosine Kinases

EGFR Protein Tyrosine Kinase Substrate

T41099

Synonym:

Target:

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

TP1269

Synonym: Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9

Target:

ALW-II-41-27

T4344

Synonym: Eph receptor tyrosine kinase inhibitor

Target: Ephrin Receptor

Target: DYRK, Haspin Kinase

Synonym: BMX kinase inhibitor

Tyrosine kinase-IN-6

Tyrosine kinase-IN-4

TAK-659 hydrochloride

T4209

Synonym: TAK-659

Target: VEGFR, FLT, Tyrosine Kinases, JAK, Syk

LFM-A13

T6217

Synonym:

Target: PLK, JAK, BTK

ALK inhibitor 1

T10285

Synonym:

Target: FAK, IGF-1R, ALK

PF-562271

T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

F-1

T11254

Synonym:

Target: ROS, ALK, ROS Kinase

GSK1838705A

T3079

Synonym:

Target: IGF-1R, JNK, S6 Kinase, ALK

PF-562271 besylate

T6177

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

Fostamatinib

T6115

Synonym: R788

Target: FLT, Syk, Monoamine Transporter, Adenosine Receptor

ALK kinase inhibitor-1

Synonym: PRN2246,SAR442168

Target: FAK, Akt, Src

AZD-3463

T1967

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

JH-VIII-157-02

T15612

Synonym:

Target: Microtubule Associated, ALK

MS4078

T16153

Synonym:

Target: ALK, Ligand for E3 Ligase

Synonym: PF-6463922,PF-06463922,Loratinib

Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase

Target: Apoptosis, FLT, c-RET, TAM Receptor, Aurora Kinase

Target: Apoptosis, ALK

PF-573228

T2001

Synonym: PF 573228

Target: Apoptosis, FAK

R406

T6174

Synonym: R-406 besylate

Target: Apoptosis, FLT, Syk

カタログ番号	製品名	別名	ターゲット
TN1433	Batatasin III		FAK , Others , Akt
	Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-...		FAK , Others , Akt
T8152	6-Demethoxytangeretin		MAPK , ALK
	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.		MAPK , ALK
T1711	Harmine	Telepathine	MAO , 5-HT Receptor , DYRK
	Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.		MAO , 5-HT Receptor , DYRK
T2811	Harmine hydrochloride	telepathine hydrochloride	5-HT Receptor , DYRK , GluR
	Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.		5-HT Receptor , DYRK , GluR
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T0610	Piceatannol	trans-Piceatannol,Astringenin	Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy
	Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is...
T3122	Fangchinoline	Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline	Apoptosis , FAK , HIV Protease , Autophagy
	Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.		Apoptosis , FAK , HIV Protease , Autophagy
T6S0033	Crotonoside	Isoguanosine,2-HYDROXYADENOSINE	Others , FLT , HDAC
	1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim...		Others , FLT , HDAC
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T4183	Lavendustin A	RG-14355,NSC 678027	EGFR , Tyrosinase
	lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.		EGFR , Tyrosinase
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
TQ0065	Pseudobufarenogin	ψ-Bufarenogin	Others
	Pseudobufarenogin (ψ-Bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.		Others
TN1096	Ginsenoside Ra1		Others , Tyrosine Kinases
	Ginsenoside Ra1 is a component from ginseng. Ginsenoside Ra1 shows significant inhibitory effects on protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation (H/R).		Others , Tyrosine Kinases
T1238	Daidzein	Isoflavone	Endogenous Metabolite , PPAR
	Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.		Endogenous Metabolite , PPAR
T1737	Genistein	NPI 031L	Apoptosis , EGFR , Endogenous Metabolite , Autophagy
	Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.		Apoptosis , EGFR , Endogenous Metabolite , Autophagy
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
Fr16741	Oxindole	Indolin-2-one	Others , HIV Protease
	Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases ...		Others , HIV Protease
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R
TN2504	1,5-Dihydroxyxanthone		EGFR , AChR
	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and...		EGFR , AChR
T83411	2,3,4,6,8-Pentahydroxy-1-methylxanthone
	2,3,4,6,8-Pentahydroxy-1-methylxanthone, a xanthone derivative of Wardomyces anomalus, exhibits significant antioxidant activities and functions as an inhibitor of the p56 lck tyrosine kinase. It has potential applicatio...

天然物製品

Batatasin III

TN1433

Synonym:

Target: FAK, Others, Akt

6-Demethoxytangeretin

Target: MAO, 5-HT Receptor, DYRK

Harmine hydrochloride

T2811

Synonym: telepathine hydrochloride

Target: 5-HT Receptor, DYRK, GluR

Nitidine chloride

T5S0761

Synonym:

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Piceatannol

T0610

Synonym: trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

Fangchinoline

T3122

Synonym: Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline

Target: Apoptosis, FAK, HIV Protease, Autophagy

Crotonoside

T6S0033

Synonym: Isoguanosine,2-HYDROXYADENOSINE

Target: Others, FLT, HDAC

Gefitinib

T1181

Synonym: ZD1839

Target: EGFR, Tyrosine Kinases, Autophagy

lavendustin A

T4183

Synonym: RG-14355,NSC 678027

Target: EGFR, Tyrosinase

Hypericin

T6S0923

Synonym: Hypericine,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Pseudobufarenogin

TQ0065

Synonym: ψ-Bufarenogin

Target: Others, Tyrosine Kinases

Daidzein

T1238

Synonym: Isoflavone

Target: Endogenous Metabolite, PPAR

Genistein

T1737

Synonym: NPI 031L

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Butein

T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Oxindole

Fr16741

Synonym: Indolin-2-one

Target: Others, HIV Protease

Orobol

TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon

Target: BCL, Caspase, PI3K

Picropodophyllotoxin

T3S0027

Synonym: AXL 1717,Picropodophyllin

Target: IGF-1R

1,5-Dihydroxyxanthone

TN2504

Synonym:

Target: EGFR, AChR

2,3,4,6,8-Pentahydroxy-1-methylxanthone

T83411

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00246	HER3/ERBB3 Protein, Rhesus, Recombinant	Rhesus	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-03024	HER3/ERBB3 Protein, Rat, Recombinant (His)	Rat	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-01944	HER2/ERBB2 Protein, Rat, Recombinant (His)	Rat	HEK293
	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth fa...
TMPY-00636	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth fa...
TMPY-02477	HER3/ERBB3 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-02813	ErbB4 Protein, Human, Rhesus, Recombinant (His)	Human,Rhesus	HEK293
	ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ...
TMPY-03719	HER2/ERBB2 Protein, Canine, Recombinant (His)	Canine	HEK293
	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth fa...
TMPY-06873	FLT3 Ligand Protein, Human, Recombinant	Human	E. coli
	FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th...
TMPY-03215	FLT3 Ligand Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th...
TMPJ-00412	VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)	Human	Human Cells
	Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ...
TMPY-03066	FLT3 Ligand Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th...
TMPY-01601	AXL Protein, Human, Recombinant (His)	Human	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-04649	ROR1 Protein, Human, Recombinant (His)	Human	HEK293
	ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 43.4 kDa. Accession number: Q01973
TMPY-00637	FLT1 Protein, Human, Recombinant (aa 1-328, His)	Human	HEK293
	Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a si...
TMPY-00930	TIE2 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play...
TMPY-01064	TIE2 Protein, Human, Recombinant (His)	Human	HEK293
	TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play...
TMPY-00882	Mer Protein, Human, Recombinant (His & hFc)	Human	HEK293
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-04330	Mer Protein, Human, Recombinant	Human	HEK293
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-01247	FLT3 Protein, Human, Recombinant (T227M, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-05394	ROR2 Protein, Human, Recombinant (His)	Human	HEK293
	ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 42.8 kDa. Accession number: Q01974
TMPY-02231	TrkB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPJ-00778	HER2/ERBB2 Protein, Human, Recombinant (His)	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPY-04384	Src Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPY-01936	VEGFR3/FLT4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-01084	TrkA Protein, Human, Recombinant (His)	Human	HEK293
	TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promot...
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-02365	HER3/ERBB3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-01296	HGFR/c-Met Protein, Human, Recombinant (His)	Human	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-02469	HER2/ERBB2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth fa...
TMPY-02314	HER2/ERBB2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth fa...
TMPY-00949	VEGFR3/FLT4 Protein, Human, Recombinant (His)	Human	HEK293
	Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-01289	DDR1 Protein, Human, Recombinant (His)	Human	HEK293
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracell...
TMPY-01389	HER3/ERBB3 Protein, Human, Recombinant (His)	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-04956	HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPJ-01017	Dtk Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Dtk, also called Tyro3, belongs to the TAM receptor family of receptor protein tyrosine kinases (RPTKs) composed of three receptors Tyro3, Axl, and Mer. These receptors share a characteristic molecular structure of two i...
TMPJ-01081	Dtk Protein, Human, Recombinant (His)	Human	Human Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs an...
TMPJ-01018	Dtk Protein, Mouse, Recombinant (mFc)	Mouse	Human Cells
	Dtk, also called Tyro3, belongs to the TAM receptor family of receptor protein tyrosine kinases (RPTKs) composed of three receptors Tyro3, Axl, and Mer. These receptors share a characteristic molecular structure of two i...
TMPY-04383	CSK Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions are also regulated by Met. The structure of a large fragment of the c-Src kinase comprises the...
TMPY-00399	HER3/ERBB3 Protein, Human, Recombinant	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-06552	AXL Protein, Rat, Recombinant (His)	Rat	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-03563	TIE2 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play...
TMPY-02508	TIE2 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play...
TMPY-05049	TIE2 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play...
TMPY-03299	FLT1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a si...
TMPH-02271	BTK Protein, Human, Recombinant (His)	Human	Baculovirus
	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...
TMPY-04377	Brk Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Tyrosine kinase (PTKs) is a protein that carries out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demonstrated to mediate malignant ce...
TMPY-00228	TrkB Protein, Canine, Recombinant (hFc)	Canine	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
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HER3/ERBB3 Protein, Rhesus, Recombinant

TMPY-00246

Species: Rhesus

Expression System: HEK293

HER3/ERBB3 Protein, Rat, Recombinant (His)

TMPY-03024

Species: Rat

Expression System: HEK293

HER2/ERBB2 Protein, Rat, Recombinant (His)

TMPY-01944

Species: Rat

Expression System: HEK293

HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)

TMPY-00636

Species: Cynomolgus

Expression System: HEK293

HER3/ERBB3 Protein, Rhesus, Recombinant (His)

TMPY-02477

Species: Rhesus

Expression System: HEK293

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

TMPY-00548

Species: Cynomolgus,Rhesus

Expression System: HEK293

ErbB4 Protein, Human, Rhesus, Recombinant (His)

TMPY-02813

Species: Human,Rhesus

Expression System: HEK293

HER2/ERBB2 Protein, Canine, Recombinant (His)

TMPY-03719

Species: Canine

Expression System: HEK293

FLT3 Ligand Protein, Human, Recombinant

TMPY-06873

Species: Human

Expression System: E. coli

FLT3 Ligand Protein, Human, Recombinant (His)

TMPY-03215

Species: Human

Expression System: Baculovirus-Insect Cells

VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

TMPJ-00412

Species: Human

Expression System: Human Cells

FLT3 Ligand Protein, Mouse, Recombinant (hFc)

TMPY-03066

Species: Mouse

Expression System: HEK293

AXL Protein, Human, Recombinant (His)

TMPY-01601

Species: Human

Expression System: HEK293

ROR1 Protein, Human, Recombinant (His)

TMPY-04649

Species: Human

Expression System: HEK293

FLT1 Protein, Human, Recombinant (aa 1-328, His)

TMPY-00637

Species: Human

Expression System: HEK293

TIE2 Protein, Human, Recombinant (His & hFc)

TMPY-00930

Species: Human

Expression System: HEK293

TIE2 Protein, Human, Recombinant (His)

TMPY-01064

Species: Human

Expression System: HEK293

Mer Protein, Human, Recombinant (His & hFc)

TMPY-00882

Species: Human

Expression System: HEK293

HGFR/c-Met Protein, Mouse, Recombinant (His)

TMPY-01896

Species: Mouse

Expression System: HEK293

Mer Protein, Human, Recombinant

TMPY-04330

Species: Human

Expression System: HEK293

FLT3 Protein, Human, Recombinant (T227M, His)

TMPY-01247

Species: Human

Expression System: HEK293

ROR2 Protein, Human, Recombinant (His)

TMPY-05394

Species: Human

Expression System: HEK293

TrkB Protein, Mouse, Recombinant (His)

TMPY-02231

Species: Mouse

Expression System: HEK293

HER2/ERBB2 Protein, Human, Recombinant (His)

TMPJ-00778

Species: Human

Expression System: Human Cells

Src Protein, Human, Recombinant (His & GST)

TMPY-04384

Species: Human

Expression System: Baculovirus-Insect Cells

VEGFR3/FLT4 Protein, Mouse, Recombinant (His)

TMPY-01936

Species: Mouse

Expression System: HEK293

TrkA Protein, Human, Recombinant (His)

TMPY-01084

Species: Human

Expression System: HEK293

TrkB Protein, Human, Recombinant (His)

TMPY-00751

Species: Human

Expression System: HEK293

HER3/ERBB3 Protein, Mouse, Recombinant (His)

TMPY-02365

Species: Mouse

Expression System: HEK293

HGFR/c-Met Protein, Human, Recombinant (His)

TMPY-01296

Species: Human

Expression System: HEK293

HER2/ERBB2 Protein, Mouse, Recombinant (hFc)

TMPY-02469

Species: Mouse

Expression System: HEK293

HER2/ERBB2 Protein, Mouse, Recombinant (His)

TMPY-02314

Species: Mouse

Expression System: HEK293

VEGFR3/FLT4 Protein, Human, Recombinant (His)

TMPY-00949

Species: Human

Expression System: HEK293

C-ABL/ABL1 Protein, Human, Recombinant (GST)

TMPY-04396

Species: Human

Expression System: Baculovirus-Insect Cells

DDR1 Protein, Human, Recombinant (His)

TMPY-01289

Species: Human

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant (His)

TMPY-01389

Species: Human

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated

TMPY-04956

Species: Human

Expression System: HEK293

Dtk Protein, Mouse, Recombinant (hFc)

TMPJ-01017

Species: Mouse

Expression System: Human Cells

Dtk Protein, Human, Recombinant (His)

TMPJ-01081

Species: Human

Expression System: Human Cells

Dtk Protein, Mouse, Recombinant (mFc)

TMPJ-01018

Species: Mouse

Expression System: Human Cells

CSK Protein, Human, Recombinant (GST)

TMPY-04383

Species: Human

Expression System: Baculovirus-Insect Cells

HER3/ERBB3 Protein, Human, Recombinant

TMPY-00399

Species: Human

Expression System: HEK293

AXL Protein, Rat, Recombinant (His)

TMPY-06552

Species: Rat

Expression System: HEK293

TIE2 Protein, Cynomolgus, Recombinant (hFc)

TMPY-03563

Species: Cynomolgus

Expression System: HEK293

TIE2 Protein, Rat, Recombinant (hFc)

TMPY-02508

Species: Rat

Expression System: HEK293

TIE2 Protein, Rhesus, Recombinant (His)

TMPY-05049

Species: Rhesus

Expression System: HEK293

FLT1 Protein, Rat, Recombinant (His)

TMPY-03299

Species: Rat

Expression System: HEK293

BTK Protein, Human, Recombinant (His)

TMPH-02271

Species: Human

Expression System: Baculovirus

Brk Protein, Human, Recombinant (GST)

TMPY-04377

Species: Human

Expression System: Baculovirus-Insect Cells

TrkB Protein, Canine, Recombinant (hFc)

TMPY-00228

Species: Canine

Expression System: HEK293

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カタログ番号	製品名
L2200	Tyrosine Kinase Inhibitor Library	1016 compounds
	A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L9410	Covalent Inhibitor Library	1920 compounds
	A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.

ライブラリー

Tyrosine Kinase Inhibitor Library

L2200

Compounds: 1016

Covalent Inhibitor Library

L9410

Compounds: 1920